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Reflux esophagitis model established by cardia plication combined with esophagoduodenostomy
Reflux esophagitis model established by cardia plication combined with esophagoduodenostomy
Background
In the esophagoduodenostomy model, end-to-end anastomosis is performed between the lower esophageal sphincter and the proximal duodenum, with preservation of the vagus nerve.
This allows gastric and duodenal secretions to reflux together into the esophagus through the anastomotic stoma.
The esophagoduodenostomy model well simulates the reflux status in patients with reflux esophagitis.
Materials and methods
- **Animals**: Male SD rats, weighing 250–300 g
- **Model establishment**: The esophagus was transected, the cardiac end was sutured and closed, and the distal esophagus was anastomosed to the duodenum. Reflux esophagitis model was successfully established after 12 weeks.
- **Evaluation indexes**: Gross observation, HE staining
- **Model establishment**: The esophagus was transected, the cardiac end was sutured and closed, and the distal esophagus was anastomosed to the duodenum. Reflux esophagitis model was successfully established after 12 weeks.
- **Evaluation indexes**: Gross observation, HE staining
Test and verify
Gross observation
Esophageal tissue HE staining
