Pulmonary veno-occlusive disease (PVOD) is a clinicopathological syndrome that can cause pulmonary hypertension. It is characterized by progressive occlusion of small pulmonary veins, leading to increased pulmonary vascular resistance and right heart failure. Pulmonary venous occlusion is recognized as one of the causes of pulmonary hypertension, involving proliferation of postcapillary veins in the interlobular septa and pre-septal regions, resulting in stenosis or even obstruction of small and minute veins. Pathologically, it is mainly characterized by diffuse and extensive fibrous obliteration of lung tissue.

SD rats (female, 220 g)

Modeling method: Mitomycin was administered intraperitoneally twice at one-week intervals; the model was successfully established after 6 weeks.

Evaluation indicators: pulmonary artery pressure measurement, right ventricular hypertrophy index, HE staining, Victoria blue staining for elastic fibers

Right ventricular hypertrophy index and pulmonary artery pressure measurement

HE staining of lung tissue

Victoria blue staining for elastic fibers of lung tissue