Hypertension is a common chronic disease characterized by elevated systemic arterial blood pressure, accompanied by a clinical syndrome of functional or organic damage to the heart, brain, kidneys, and other organs. It is the most important risk factor for the onset and death of cardiovascular and cerebrovascular diseases, with approximately half of cardiovascular‑ and cerebrovascular‑related deaths attributable to hypertension. Clinically used antihypertensive drugs still have many limitations in lowering blood pressure and improving symptoms. Many aspects of the exact etiology and pathogenesis of hypertension remain unclear, and there is an urgent need to strengthen research in these areas to develop more effective therapeutic agents. Experimental studies rely heavily on animal models of hypertension, and ideal models can well simulate the pathological state of the disease. To better investigate the pathogenesis and treatment of hypertension, researchers have established various experimental animal models, which fall into two main categories: gene‑related hypertensive animal models (including hereditary hypertension models and genetically engineered hypertensive animal models) and non‑gene‑related hypertensive animal models.

SHR rats (male, 10 weeks old), with WKY rats as the control group

Modeling method: Spontaneous hypertension model; blood pressure was measured before grouping.

Evaluation indicators: systolic blood pressure, diastolic blood pressure, serum/plasma ELISA, HE staining

Systolic blood pressure, diastolic blood pressure

Serum / plasma ELISA

HE staining of carotid artery tissue