Diabetes mellitus is a metabolic clinical syndrome. With improved living standards, population aging and rising obesity rates, its incidence is increasing year by year. Persistent hyperglycemia causes chronic damage and dysfunction to various tissues, especially the eyes, kidneys, heart, blood vessels and nerves. Currently, there are various animal modeling methods for diabetes mellitus (DM). Chemically induced DM animal models involve using chemical agents to damage pancreatic β‑cells, resulting in insulin deficiency and experimental diabetes. Commonly used drugs include alloxan and streptozotocin (STZ).

C57 mice (male, approximately 25 g)
Modeling method: Intraperitoneal injection of STZ to induce type 1 diabetes mellitus model
Evaluation indicators: Blood glucose detection, body weight detection, HE staining

Blood glucose detection

Body weight measurement

HE staining of liver tissue