Bronchopulmonary dysplasia (BPD) is a chronic lung disease pathologically characterized by alveolar simplification, pulmonary vascular hypoplasia, accompanied by pulmonary fibrosis, atelectasis and cystic lesions. It predominantly occurs in premature infants, and its adverse impacts on cardiopulmonary function and neurodevelopment can persist into adulthood. First reported in 1967, the incidence of BPD has remained at a high level. In the United States, the incidence of BPD in extremely preterm infants and extremely low birth weight infants (gestational age ＜ 28 weeks / birth weight ＜ 1000 g) is approximately 40%, with no significant decline in the past two decades. In China, the BPD incidence of such high-risk premature infants exceeds 50%.

SD immature rats (male and female, 4 days old)
Modeling method: Intraperitoneal injection of LPS was performed, and the bronchopulmonary dysplasia model was successfully established after a period of intervention.
Evaluation index: HE staining

Pulmonary tissue HE staining