Intranasal injection of Staphylococcus aureus into the rat sinus cavity is used to establish non-rhinogenic bacterial sinusitis. The rat sinusitis model constructed via surgical intervention features a high modeling success rate and a short modeling cycle.

SD rats (mixed gender, approximately 200 g)
Modeling method: A gelatin sponge was placed into the drilled maxillary sinus, followed by instillation of a certain concentration of Staphylococcus aureus. A bacterial sinusitis model was successfully established after a period of intervention.
Evaluation index: HE staining