Carrageenan is a water-soluble sulfated polysaccharide extracted from red algae such as Chondrus crispus, Gigartina and Eucheuma. It is also regarded as a heparinoid polysaccharide and a type of sulfated galactan. Carrageenan is widely used to establish various inflammatory models and inflammatory pain models. In relevant studies, carrageenan is dissolved in normal saline and injected into the seminal vesicles of rats. Twenty-four hours after injection, obvious interstitial edema in the rat prostate can be observed, accompanied by extensive infiltration of inflammatory cells including lymphocytes, monocytes and segmented neutrophils. The secretion in glandular cavities is reduced or even exhausted, with massive inflammatory cells and exfoliated glandular epithelial cells accumulated in the tissue. In addition, the leukocyte count in prostatic fluid increases while lecithin bodies decrease, and bacterial culture of prostatic fluid presents a negative result, which is consistent with the diagnostic characteristics of clinical non-bacterial prostatitis.

SD rats (male, approximately 250 g)
Modeling method: Carrageenan normal saline solution was injected into each bilateral ventral prostate lobe. The prostatitis model was successfully established 24 hours later.
Evaluation index: HE staining

HE staining of prostate tissue