A traumatic infection model is a subclass of infection models complicated with trauma as an underlying disease, belonging to composite animal models. In this model, trauma serves as a prerequisite for the occurrence of infection. Animals often exhibit disorders of multiple physiological functions such as immunity and coagulation after trauma, rendering susceptibility to infection, severity and prognosis more complex than those in single infection models. According to different modes of combined infection, current common traumatic infection models can be divided into two main categories: animal models of spontaneous infection at traumatic sites and animal models of traumatic sites combined with exogenous infection. This model is widely used in studies related to skin defect repair and topical anti-infective medication.

SD rats (male or female, 6–8 weeks old)
Modeling method: After skin incision and sharp dissection, Staphylococcus aureus was injected into the fascial layer of the wound. A traumatic infection model was successfully established 7 days later.
Evaluation indicators: Calculation of skin healing rate, HE staining

HE staining of wound skin