Biliary cirrhosis can be induced by artificially causing extrahepatic biliary obstruction through methods such as ligation, transection of the bile duct, or injection of sclerosants. This leads to dilatation of bile ducts proximal to the obstruction, cholestasis, and increased intrabiliary pressure. Intrahepatic blood vessels are compressed by dilated bile ducts, accompanied by bile extravasation, resulting in hepatocellular bile pigment deposition, degeneration and necrosis. Proliferation of fibrous tissue extends toward the bile ducts and causes lobular remodeling, ultimately leading to hepatic fibrosis and cirrhosis.

SD rats (female, sex unlimited, 200–250 g)
Modeling method: The biliary cirrhosis model was established by ligating and transecting the common bile duct.
Evaluation indicators: portal venous pressure measurement, HE staining, Sirius Red staining

Portal venous pressure measurement

HE staining of liver tissue

Sirius Red staining of liver tissue