Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is clinically characterized by fever, rash, cervical lymphadenopathy, bulbar conjunctival hyperemia, cracked lips, stiff swelling of hands and feet, and erythema on the palms and soles. KD is an autoimmune vasculitis syndrome whose main pathological changes are systemic inflammatory lesions of medium and small arteries, predominantly involving the coronary arteries. It can cause coronary artery lesions (CAL) and coronary arteritis. Animal models of this disease are mostly established by induction with **Lactobacillus casei** cell wall extract or bovine serum albumin. Mice will present with thickened coronary vascular walls, infiltration of inflammatory cells such as neutrophils and lymphocytes, as well as inflammatory cell infiltration and extensive myocardial rupture in the myocardium.

BALB/c mice (male, 7–8 weeks old)
Modeling method: Bovine serum albumin was administered intraperitoneally 7 times within 14 days. The Kawasaki disease model was successfully established 16 days after the first injection of bovine serum albumin.
Evaluation indicators: gross observation, HE staining, Masson staining

gross observation

HE staining of myocardial tissue

HE staining of coronary artery

Masson staining of myocardial tissue