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Electrical Stimulation-Induced Atrial Fibrillation Model

Background
Atrial fibrillation (AF) is a common arrhythmia. Establishing suitable animal models for AF is crucial for investigating its mechanisms and developing treatments. Rapid atrial pacing induces myocardial electrical and structural remodeling, leading to AF, and remains the most widely used method. Depending on experimental objectives, electrodes can be placed in the atrial appendage, nerves, pulmonary veins, or other locations. Pacing can be performed at a single site or at multiple sites simultane
Materials and methods
SD rats (male, 8 weeks old)
Modeling Method: Rapid atrial pacing via esophageal electrodes can induce atrial fibrillation, thereby establishing an atrial fibrillation model.
Evaluation Criteria: Electrocardiogram, Masson\'s trichrome staining
Test and verify

心电图


心肌组织Masson染色