Position：Home >
Transverse Aortic Constriction Model
Transverse Aortic Constriction Model
Background
1.Definition of the Model: Transverse aortic constriction (TAC) accounts for approximately 1.1%–3.4% of congenital cardiovascular anomalies. The constriction typically occurs in the aortic isthmus or distal left subclavian artery and is generally classified as preductal or postductal. The constriction range is usually limited, though long-segment constrictions are occasionally observed. During constriction development, extensive collateral circulation may form. The TAC-induced left ventricular h
Materials and methods
1. Experimental Animals (Strain, Age, Sex): Rat Strains: SD, Wistar; Mouse Strains: C57BL/6, BALB/C; and other strains; Age: 6-8 weeks; Male.
2. Brief Description of Modeling Method: After anesthesia, a transverse incision (approximately 1.5 cm) is made on the mouse parallel to the midline of the upper limbs. Transect the sternum between the first and second ribs. Bluntly dissect the thymus to expose the aortic arch and its branches. Create a small opening in the fascia between the aortic arch,
2. Brief Description of Modeling Method: After anesthesia, a transverse incision (approximately 1.5 cm) is made on the mouse parallel to the midline of the upper limbs. Transect the sternum between the first and second ribs. Bluntly dissect the thymus to expose the aortic arch and its branches. Create a small opening in the fascia between the aortic arch,
Test and verify
模型示意图
超声检测
